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Readthrough Therapies for RYR-1-Related Disease Due to Nonsense Variants Research Grant Awards
Targeted Request for Grant Application

Deadline: May 1, 2026

The RYR-1 Foundation is pleased to invite investigators to submit a Request for Proposal (RFP) focused on the following Research Priority Area (RPA)

• Readthrough Therapies for RYR-1-Related Disease (RYR-1-RD) due to Nonsense Variants
  • This RPA is the focus of this RFP for the following reasons: 1) The clinical severity of RYR-1-RD patients with nonsense variants, 2) The ongoing development of a nonsense RYR-1-RD mouse model (see details below), and 3) The growing field of readthrough therapies, including both small molecules and tRNA-based therapies. 

Summary of Application Format:

1. Title Page (Project Title) of the RYR-1-Related Diseases (RYR-1-RD) Project
2. Enable Other Users to Access this Proposal
3. Information/Acknowledgements
4. Applicant/PI
5. Institution & Contacts
6. Key Personnel (including a short curriculum vitae or NIH Biosketch)
7. Abstract 
8. Impact Statement
9. Preliminary/Supporting Data
10. Budget Period Detail
11. Budget Summary and Justification
12. Organization Assurances
13. Attachments
14. Signature Page

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