It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors
Authors: Raika Pancaroglu and Filip Van Petegem
Overview
In this issue of Structure, Melville and colleagues used cryo-EMto study the binding of ryanodine receptors to Rycals, compounds with the potential to treat skeletal and cardiac muscle disorders. Unexpectedly, they found that Rycal packs against an ATP in a peripheral pocket, which stabilizes the closed channel state.
