Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor
Authors: Gaetano Santulli, Daniel R. Lewis, Andrew R. Marks
Overview
Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
Keywords: Calcium · Excitation–contraction coupling · Muscular dystrophy · RyR1 · Skeletal muscle
